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The Clinical High-Risk state for psychosis (CHR-P) paradigm was introduced about 2 decades ago and over this period of time, accumulating knowledge has been gained leading to conceptual advancements. These advancements involve new knowledge into risk enrichment and the impact of recruitment strategies, specificity for prediction of psychotic and non-psychotic mental disorders, and heterogeneity of psychosis risk among the different CHR-P subgroups. The current special issue advances current knowledge on deconstructing the CHR-P paradigm across its 3 subgroups: genetic risk, attenuated psychotic symptoms, and short-lived and remitting psychotic episodes. A conceptual revision of the paradigm (Version II) is suggested and supported by 3 original studies published in this special issue.