Is there only one best titration standard for starting clozapine?

A clozapine titration plan should be individualized based on a number of factors. This includes age, gender, smoking status, other medications, race/ethnicity, and clinical urgency. Published sample inpatient titrations are generally faster than outpatient ones. Slower titrations may be less likely to result in clozapine-induced myocarditis and may help to prevent early discontinuation or settling on a dose that is too high for the patient. Prescribers need to be flexible when they conduct new clozapine titrations. You may need to adjust the plan as the titration continues. For more about how to titrate clozapine, see this post from SMI Adviser.

Learn more about common myths around clozapine. See our infographic on this topic.

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REFERENCES

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